While ClearView Flex can take multiple inputs simultaneously (HDMI and HD-SDI), only one video output is possible per Flexbox (The ClearView Flex encoder).
In the event the presenter wants to show the HDMI input (i.e. to share their desktop for Adobe or Avid timeline) and HD-SDI input (i.e. the output from Adobe, Avid, Flame, etc) at the same time, you will need two Flexboxes.